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The nonlinear and unsteady sets of differential equations are solved by the finite-difference method. The results are compared with different equations as well as with the available experimental data. Erythema induratum of Bazin associated with Addison's disease: first description. The differential diagnosis includes diseases like nodular vasculitis, perniosis, polyarteritis nodosa and erythema nodosum.

Anti-tuberculosis drugs and glucocorticoid replacement led to disappearance of the signs and symptoms. It should be borne in mind that tuberculosis is an important etiological factor for Addison's disease. Seronegative necrolytic acral erythema : A distinct clinical subset? Full Text Available A patient was referred to us with asymptomatic, erythematous, nonitchy, scaly lesions present bilaterally on the dorsa of his feet and toes since the last 2 months.

Both the legs had pitting edema as well. There were hyperkeratosis, focal parakeratosis, acanthosis and scattered spongiosis in the epidermis, and proliferation of capillaries with perivascular infiltration of lymphomononuclear cells in the dermis. There was no serological evidence of hepatitis C virus.

Laboratory investigations revealed hypoalbuminemia and low-normal serum zinc. On clinicopathological correlation, we made a diagnosis of necrolytic acral erythema NAE. The lesions responded dramatically to oral zinc sulfate and topical clobetasol propionate within 3 weeks with disappearance of edema and scaling and only a minimal residual erythema.

NAE with negative serology for hepatitis C may be viewed as a distinct subset of the condition that had been originally described. Idiopathic granulomatous mastitis IGM is a benign, aseptic inflammatory disease of unknown origin, which must be distinguished from tumoral and infectious processes that affect the breast, including tuberculosis.

IGM is a rare cause of erythema nodosum, but it is useful for dermatologists to be aware of this association. A year-old nulliparous woman presented with erythema nodosum, arthralgia and fever. On examination, she had a firm and painful mass of 5cm in the right breast with retraction and axillary adenopathy. The breast lump developed gradually over the preceding 4 months.

Although two biopsies showed no evidence of atypical cells, inflammatory areas and a granulomatous process were seen. Culture of breast tissue for mycobacteria was negative. A diagnostic of idiopathic granulomatous mastitis was made. Systemic corticosteroids led to a reduction in size of the mass, but relapse occurred in the contralateral breast on dose-reduction of the corticosteroids. IGM is a rare disease of unknown aetiology. Diagnosis is based on characteristic histological features and exclusion of other granulomatous diseases.

Extra-mammary signs are rare and include erythema nodosum, arthralgia and episcleritis. Management is poorly codified. Angioplastic necrolytic migratory erythema. Unique association of necrolytic migratory erythema , extensive angioplasia, and high molecular weight glucagon-like polypeptide. A diabetic patient developed necrolytic migratory erythema with extensive angioplasia and high molecular weight glucagon-like polypeptide.

There was no associated neoplasm such as glucagonoma. Lesions in the skin were studied by standard optical microscopy and by radioautography after incorporation of tritiated thymidine. Alterations in the skin begin as focal necrosis in the epidermis and in epithelial structures of adnexa, followed by marked angioplasia and a superficial and deep perivascular dermatitis.

Erythema multiformas sociated with herpes virus: case report. The case of a 36 year old male patient presenting to emergency of HNAL with fever, malaise, itching and painful ulcer type lesions in oral cavity, multiple target lesions in upper and lower limbs, penis, and perianal region is reported. The diagnosis was EM Major. Ulcerous lesions in oral cavity and target lesions in hands were the most salient.

Hair-dye induced erythema multiforme like allergic contact dermatitis. Full Text Available Erythema multiforme EM is an acute, self limited skin disease characterized by the sudden eruption of symmetrical lesions in typical targetoid fashion usually confined to face and extremities. The most commonly implicated factors include infections like herpes simplex, mycoplasma, drugs like antibiotics and anticonvulsants and vaccinations. Contact dermatitis induced EM is a rarely reported entity.

Herein we present a case of a 40 year old female who presented with EM due to contact sensitivity to p-Paraphenylenediamine PPD, a common coloring agent in hair-dyes and a potent sensitizer. One of the most important issues in modern volcanology is the assessment of volcanic risk, which will depend - among other factors - on both the quantity and quality of the available data and an optimum storage mechanism.

This will require the design of purpose-built databases that take into account data format and availability and afford easy data storage and sharing, and will provide for a more complete risk assessment that combines different analyses but avoids any duplication of information. Data contained in any such database should facilitate spatial and temporal analysis that will 1 produce probabilistic hazard models for future vent opening, 2 simulate volcanic hazards and 3 assess their socio-economic impact.

We describe the design of a new spatial database structure, VERDI Volcanic managEment Risk Database des Ign , which allows different types of data, including geological, volcanological, meteorological, monitoring and socio-economic information, to be manipulated, organized and managed. The root of the question is to ensure that VERDI will serve as a tool for connecting different kinds of data sources, GIS platforms and modeling applications.

We present an overview of the database design, its components and the attributes that play an important role in the database model. The VERDI database will provide scientists and decision makers with a useful tool that will assist to conduct volcanic risk assessment and management. Erythema multiforme and Stevens-Johnson syndrome following radiotherapy. Erythema multiforme EM and Stevens-Johnson syndrome SJS are thought to be hypersensitivity syndromes with various causes, and radiotherapy might be one of the causes of these syndromes.

The first case was a year-old woman with breast cancer. At the end of postoperative radiotherapy with 60 Gy, severe pruritic erythema appeared in the irradiated area and spread over the whole body. She was diagnosed with EM by a skin biopsy. The second case was a year-old woman with uterine cervical cancer who underwent postoperative radiotherapy.

At a dose of Although without any histological confirmation, SJS was strongly suspected because of her pruritic conjunctivitis. Full Text Available Erythema nodosum EN is a dermatosis of unclear etiology, which is characterized by vascular lesion of the skin; it shows itself as hard painful nodes occurring in the derma or subcutaneous fat on the shins and thighs. EN has been described in many chronic infectious processes with some features of its clinical course. In most cases, the disease is regarded as a nonspecific immunoinflammatory response to a wide spectrum of etiological factors, including that in gestation, which presents certain problems in curing the patient.

The example given below supports the need for timely testing for infectious markers in pregnancy and, in case of evolving EN, for using not only nonsteroidal anti-inflammatory drugs, but also pathogenetic treatment. Characteristics of patients presenting with erythema nodosum and sarcoidosis. We explored the relationship between erythema nodosum EN and sex, age, serum angiotensin converting enzyme ACE , bronchoalveolar lavage lymphocytosis BAL-I , interstitial granulomas and radiological stage in patients presenting with pulmonary sarcoidosis in Ireland.

Sixty-nine patients diagnosed with sarcoidosis between and were studied. There were no correlations between serum ACE, interstitial granulomas and disease stage. In this study, one quarter of patients with sarcoidosis presented with EN among their presenting features. These patients were more likely to be young females with early stage radiological disease. The management of oral erythema multiforme in juvenile patient.

The oral mucosa looks severely inflamed, but the feature are non specific and usually a biopsy is required in order to confirm the diagnosis. Cracked, bleeding, Crusted, swollen and ulcers of the lips is very characteristic of erythema multiforme, and lip involvement may cause significant morbidity. EM is assumed as an immune complex disorder which rises as a result of an immune response to an external agent such as herpes simplex virus or various drugs.

We reported: year girl, complained she suffered from painful oral ulceration for one week. One weeks advance the patient received a treatment of paracetamol and paramex for febris, headache and cough. Clinical examination of the skin showed no signs of cutaneous involvement. Other site such as the conjunctival, and genital were also free of lesions.

The patients had several red-based superficial erosions on the upper and lower lips accompanied by crusting and bleeding. Intra oral findings showed multiple irregular erosions, ulcers and intense erythematous areas, mainly on the labial mucosa. The clinical diagnosis of EM was concluded by anamnesis and clinical appearance, with differential diagnosis of secondary herpes infection herpes labialis and pemphigus vulgaris. Systemic and topical corticosteroid therapy is frequently used to treat EM Although it may partially suppress the disease.

Objective: This report explains and describes the management of patients with EM which may help dentists to determine an accurate diagnosis to avoid further complication and to give medical intervention to the disease. Conclusion: Early recognition of this disease may prevent delayed diagnosis and incorrect treatment. Discrimination between cutaneous pigmentation and erythema : comparison of the skin colorimeters Dermacatch and Mexameter. Reproducibility and specificity of the present skin colorimeters is still limited as alterations in erythema can bias the measurement of melanin and vice versa.

Repeated measurements with both devices were initially collected on colour charts. Interestingly, Mexameter's melanin and erythema values were falsely affected by an increase in erythema or variation in pigmentation respectively. On the contrary, Dermacatch's melanin and erythema values remained constant in the same circumstances.

Furthermore, as Mexameter was at least twice less reproducible than Dermacatch, Mexameter showed an increased risk of a confusion over the detection of erythema or melanin fluctuations. The analysis of more than 18, measures indicated that, Dermacatch has a significantly higher specificity and reproducibility than Mexameter in the measurement of skin pigmentation and erythema.

We describe two cases of recurrent erythema multiforme, both associated to infection with herpes simplex virus. The importance of subclinical herpes is illustrated. Antiviral and additional treatment is described Full Text Available SUMMARYSecondary hyperparathyroidism is one of the main deragements caused by chronic renal failure, and parathyroid hormone is considered one of the toxins of the uremic syndrome.

Prolonged fever due to primary hyperparathyroidism have already been described in the literature but not yet as induced by secondary hyperparathyroidism. In this case report a patient suffering from an erythema nodosum and prolonged fever associated to secondary hyperparathyroidism that disappeared through subtotal parathyroidectomy is presented. El sindrome febril prolongado secundario a hiperparatiroidismo primario ya ha sido descripto en la literatura, aunque no lo ha sido aun el inducido por hiperparatiroidismo secundario.

Full Text Available Cutaneous vasculitis can be cause by multiple disorders or can be idiopathic. Many diseases can present with similar findings, therefore histopathologic examination is always require for confirming the right diagnosis. The erythema elevatum diutinum EED is a localized vasculitis, classified as a neutrophilic dermatosis.

They have a symmetric distribution and can be asymptomatic, painful; or pruritic, sometimes accompanied paresthesias. The most common clinical presentation is round erythematous papules which become erythemato-violaceous or purpuric plaques. There are not pathognomonic histopathological findings, but can present as a leukocytoclastic vasculitis with perivascular neutrophilic infiltration in the middle and superficial dermis. I presented the case of a year-old female, with erythematous purpuric painful plaques, irregular, symmetric and elevated, located in both thenar regions of her hands and paresthesias.

This patient does not have all the clinical progression and outcome, due to the initial stage of the disease. Towards understanding the pathology of erythema nodosum leprosum. Erythema nodosum leprosum ENL is an immune-mediated complication of leprosy presenting with inflammatory skin nodules and involvement of multiple organ systems, often running a protracted course.

Immune complex production and deposition as well as complement activation have long been regarded as the principal aetiology of ENL. However, new data show that cell-mediated immunity is also important. We have performed a critical analysis of studies on the pathology of ENL. Our main findings are as follows. There is deposition of immune complexes and complement together with Mycobacterium leprae antigens in the skin.

Changes in serum levels of Igs indicate a transient, localised immune response. Keratinocyte 1a and intercellular adhesion molecule-1 ICAM-1 have been shown to be present in the epidermis in ENL, which is evidence of a cell-mediated immune response. Co-stimulatory molecules such as B have also been studied but further work is needed to draw strong conclusions.

We also highlight potential areas for future research. Caecal cancer presenting as leg erythema and a lung opacity. Necrotising infection of the lower limb is a rare presentation for colorectal malignancy. We report a case of a perforated caecal adenocarcinoma presenting with right leg erythema , pain and swelling in the presence of a right lower lobe lung opacity. Following initial debridement and washout, CT imaging demonstrated a thickened terminal ileum, caecum and appendix, in keeping with primary malignancy.

This fed the right-sided lower limb sepsis tracking down from the medial aspect of the psoas muscle to give rise to the multiloculated collection seen in the adductor compartment. The patient was successfully managed with a subtotal colectomy and an end ileostomy. The biopsy confirmed an adenocarcinoma T4N1M1.

We highlight the importance of perforated colonic carcinoma as a leading differential for lower limb abscesses. Suspicions should be raised further if accompanied by rounded opacifications on plain film radiography of the lungs. No commercial use is permitted unless otherwise expressly granted. Erythema -directed digital photography for the enhanced evaluation of topical treatments for acne vulgaris. Erythema -directed digital photography is a novel method for evaluating the efficacy and tolerability of topical acne treatments.

Erythema -directed digital photography revealed background erythema from previous topical acne treatments that was not evident from standard clinical photographs and allowed a better visualization of both inflammatory and non-inflammatory lesions. In all patients, there was a clear improvement in background erythema and a reduction in acne lesions following treatment with Clin-RA.

This study has demonstrated for the first time that erythema -directed digital photography can enhance the evaluation of the efficacy and tolerability of topical acne treatments. Measurement of erythema and tanning responses in human skin using a tri-stimulus colorimeter. A 'Minolta Tri-Stimulus Colorimeter II' was evaluated for obtaining objective measurements of early changes in erythema and tanning. The meter showed a subtle, continuous transition between the primary erythematous response and the delayed tanning of skin which was below the visual threshold for detection.

This capability of the tri-stimulus colorimeter to simultaneously evaluate the hue and saturation of skin color affords an improved opportunity to quantitate the transition from erythema to tanning without subjective bias. Side-effects to the use of laptop computers. The use of laptop computers is increasing, and many children and young adults spend hours with their laptops on their laps daily. We report a case with erythema ab igne on the thigh of a year-old girl, induced by use of laptop computers four to five hours daily for nine months Photoreactivation of UV-induced pyrimidine dimers and erythema in the marsupial Monodelphis domestica.

Post-UV treatment of the gray, short-tailed opossum Monodelphis domestica with photoreactivating light nm suppressed the appearance of UV-induced erythema as evidenced by an increase in the dose of UV required to elicit an erythemal response. Pre-UV exposure to photoreactivating light had no effect on the UV induction of erythema.

The dose-response for the photoreversal of pyrimidine dimers in epidermal DNA of M. These data not only support the notion that DNA is the primary chromophore involved in the induction of erythema but also identify pyrimidine dimers as the major DNA change responsible for its induction.

These results also identify M. Intrarater reliabilities from 3 cross-sectional and prospective studies are reported. Skin hydration and erythema levels assessed using the SD Internal consistency of erythema measures was variable, ranging from low to high reliability, particularly among predebridement measures. Using the protocols outlined in this study, the SD demonstrates high reliability for assessing skin hydration and erythema levels. It is possible that the SD can be used in clinical practice as an appropriate tool for skin hydration and erythema assessment.

Full Text Available We investigated the hypothesis that patients developing high-grade erythema of the breast skin during radiation treatment could be more likely to present increased levels of proinflammatory cytokines which may lead, in turn, to associated fatigue. Forty women with early stage breast cancer who received adjuvant radiotherapy were enrolled from to Seven A seeming increase of fatigue, erythema , and proinflammatory markers was observed between the fourth and the fifth week of treatment followed by a decrease after RT.

There were no significant effects of hormone therapy, breast volume, and anemia on fatigue. Our study seems to suggest that fatigue is related to high-grade breast skin erythema during radiotherapy through the increase of cytokines levels. Effects of ultraviolet radiation, visible light, and infrared radiation on erythema and pigmentation: a review. The effects of ultraviolet radiation, visible light, and infrared radiation on cutaneous erythema , immediate pigment darkening, persistent pigment darkening, and delayed tanning are affected by a variety of factors.

Some of these factors include the depth of cutaneous penetration of the specific wavelength, the individual skin type, and the absorption spectra of the different chromophores in the skin. UVB is an effective spectrum to induce erythema , which is followed by delayed tanning. UVA induces immediate pigment darkening, persistent pigment darkening, and delayed tanning.

Visible light has been shown to induce erythema and a tanning response in dark skin, but not in fair skinned individuals. Infrared radiation produces erythema , which is probably a thermal effect. In this article we reviewed the available literature on the effects of ultraviolet radiation, visible light, and infrared radiation on the skin in regards to erythema and pigmentation.

Much remains to be learned on the cutaneous effects of visible light and infrared radiation. Time-dose relationship of erythema in high energy photon irradiation therapy. Skin doses of patients who were treated with high energy ionizing irradiation during conventional irradiation therapy were measured by thermoluminescence dosimeter TLD. In 87 of the patients, acute hyperemic change of the skin erythema of the irradiated region was observed.

In the other 13 patients, alopetia of the scalp was observed. The following conclusions were reached. The time-dose relationship was linear when erythema tolerance was used as an index, but not when alopecia was used. The tolerance dose for erythema was lower than previously reported.

The slope of the isoeffect curve on the log-log plot of total absorbed skin dose against total number of days after the first irradiation was 0. This number is larger than previously reported results. We considered that erythema is significantly influenced by fraction size and that hyperfractionation is a promising method of irradiation, especially in Japan. Combined use of chemotherapeutic agents, such as 5-FU, accelerated erythema.

The slope of combined treatment was 0. Observing acute hyperemic change of skin is considered to be a useful method of investigating the combined effects of chemotherapeutic agents on irradiation. Prolonged ultraviolet light-induced erythema and the cutaneous carcinoma phenotype.

A considerable amount of evidence exists in support of the role of ultraviolet radiation as a major etiologic factor in human skin cancer, both melanoma and carcinoma types. On the basis of epidemiologic studies a phenotype has been described which helps to identify the persons who are more susceptible to skin cancer.

In an attempt to further define this population, patients with cutaneous carcinoma and a normal control group were exposed to artificial ultraviolet light UVL and the erythema and tanning responses of each group were measured over a day period.

UVL-induced erythema was prolonged in a significantly higher percentage of patients with skin cancer than in control patients, lasting two to three weeks after single exposures to 6 and 8 times the patient's minimal erythema dose. The presence of prolonged erythema correlated with this history of previous skin cancer but did not correlate with other established risk factors for cutaneous carcinoma, i.

Prolonged erythema following UVL radiation may therefore represent an additional risk factor and help to identify the skin cancer-susceptible population. Erythema multiforme and Stevens-Johnson syndrome in patients receiving cranial irradiation and phenytoin. In 15 months we encountered eight patients with intracranial tumors who developed erythema multiforme EM or erythema multiforme bullosa Stevens-Johnson syndrome.

The clinical picture differed from the classic form of EM in that the erythema began on the scalp and spread to the extremities, progressing in three cases to extensive bullous formation. The pathogenesis of the disorder is probably immunologic. In the absence of seizures, anticonvulsants should not be given routinely to patients with brain tumors.

Erythema multiforme like allergic contact dermatitis associated with laurel oil: a rare presentation. This reaction may present with several clinical manifestations. Erythema multiforme-like allergic contact dermatitis is a rare type of non-eczematous contact dermatitis, which may lead to difficulty in diagnosis. Essential oil of Laurus nobilis is widely used in massage therapy for antiinflammatory and analgesic effects. Laurus nobilis induced contact dermatitis has been reported in the literature but an erythema multiforme-like presentation is rare.

Erythema gyratum repense like eruption in bullous pemphigoid: A case report. Full Text Available Bullous pemphigoid BP is an autoimmune disease characterized by presence of bullous eruption on the trunk and extremities especially flexural aspects of the limbs. This disease usually occurs in the elderly. The initial presentation of BP is variable. An urticarial or erythematous rash may precede the appearance of the blister formation and can be associated with itch or pruritus.

We presented 87 year old bedridden man diagnosed with BP who initially presented with erythema gyratum repens like eruption before blister formation. This case report discusses the presentation of figurate erythema in non-bullous phase of BP for clinicians. Ab initio pseudopotential theory. The ab initio norm-conserving pseudopotential is generated from a reference atomic configuration in which the pseudoatomic eigenvalues and wave functions outside the core region agree with the corresponding ab initio all-electron results within the density-functional formalism.

This paper explains why such pseudopotentials accurately reproduce the all-electron results in both atoms and in multiatomic systems. In particular, a theorem is derived to demonstrate the energy- and perturbation-independent properties of ab initio pseudopotentials. Ngcungcu, T. Keratolytic winter erythema KWE is a rare autosomal-dominant skin disorder characterized by recurrent episodes of palmoplantar erythema and epidermal peeling. KWE was previously mapped to 8p Using targeted resequencing of the KWE critical.

Erythema nodosum and the risk of tuberculosis in a high incidence setting. Het voorkomen van tekebeten en Erythema migrans in de huisartsenpraktijken in Nederland. Mil, de E. Lyme disease is a bacterial, infectious disease caused by the spirochete Borrelia burgdorferi.

The aim of this study was to get information about the geographic distribution of the occurrence of tick bites and erythema migrans in the Netherlands and the association with possible risk factors. Underprediction of human skin erythema at low doses per fraction by the linear quadratic model.

Hamilton, Christopher S. Background and purpose. The erythematous response of human skin to radiotherapy has proven useful for testing the predictions of the linear quadratic LQ model in terms of fractionation sensitivity and repair half time. No formal investigation of the response of human skin to doses less than 2 Gy per fraction has occurred. This study aims to test the validity of the LQ model for human skin at doses ranging from 0.

Materials and methods. Complete erythema reaction profiles were obtained using reflectance spectrophotometry in two patient populations: 65 patients treated palliatively with 5, 10, 12 and 20 daily treatment fractions varying thicknesses of bolus, various body sites and 52 patients undergoing prostatic irradiation for localised carcinoma of the prostate no bolus, fractions.

Results and conclusions. Gender, age, site and prior sun exposure influence pre- and post-treatment erythema values independently of dose administered. Out-of-field effects were also noted. The linear quadratic model significantly underpredicted peak erythema values at doses less than 1. This suggests that either the conventional linear quadratic model does not apply for low doses per fraction in human skin or that erythema is not exclusively initiated by radiation damage to the basal layer.

The data are potentially explained by an induced repair model. Erythema persists longer than one year in split-thickness skin graft donor sites. Transepidermal water loss TEWL , erythema and pigmentation were measured quantitatively using non-invasive devices Although there have been some studies about changes of skin erythema and pigmentation following ultraviolet radiation in other races, the relevant data in Chinese have never been achieved.

Thus, we evaluated the long-time course of skin erythema , pigmentation and hydration changes after different doses of solar-simulated ultraviolet SSUV irradiation in 26 Chinese women for days. The erythema index increased abruptly and peaked during 3 days of SSUV exposure, then slowly returned to the baseline level starting at day 7 and completely recovered during day course of this study only in one minimal erythema doses MED SSUV irradiation.

The melanin index started to slowly increase at day 3 of SSUV exposure, peaking at day 14 and gradually returned to the baseline level thereafter, but did not return to the baseline level during day course in all doses. Skin hydration slowly declined at day 3 of exposure, hitting the lowest point at day 7, then slowly recovered starting at day 14 and completely returned to the baseline level at day 28 only in 1.

These results will serve as baseline data on Chinese skin and provide useful references for the treatment of serious skin photodamage in Chinese. Recall of UVB-induced erythema in breast cancer patient receiving multiple drug chemotherapy. One day after sunbathing, a breast cancer patient received intravenous methotrexate, cyclophosphamide and 5-fluorouracil and had a recall of her UV erythema over the following week.

In this paper erythema effective UV radiant exposure data from the PHE solar network Chilton site for the 25 year period from to are presented. The year with the highest average daily erythema effective radiant exposure was at J m -2 and the year with the lowest average daily radiant exposure was at J m Overall, the average daily radiant exposure per year ranged from J m -2 to 9.

A preliminary analysis of the data set is carried out. Thereafter a small decrease in annual erythema effective radiant exposure of 0. In terms of seasonal analyses, a statistically significant increase in erythema effective UV radiant exposure of 5. The data suggest that the erythema effective UV dose available for impacting public health has been decreasing in recent years. Erythema migrans and serodiagnosis by enzyme immunoassay and immunoblot with three borrelia species.

There is wide divergence of opinion between physicians regarding the use of serological measures for the diagnosis and treatment of erythema migrans, the hallmark of Lyme borreliosis. We studied the outcome of an enzyme immunoassay and immunoblot Western blot used on the sera of patients who had suffered tick bite and erythema migrans, and had been subsequently treated with various antibiotics.

Ninety-nine consecutive patients presenting with erythema migrans after tick bite were prospectively recruited at the outpatient department of two Vienna City hospitals and at the consultation office for Lyme borreliosis of the Institute of Hygiene. University Vienna. Blood samples were taken before antibiotic treatment and 3 and 6 months thereafter.

Blood samples from blood donors served as controls. The latter was performed with isolates of B. The 4 interpretation criteria for immunoblot results were: A 3 bands out of 8 , B 2 bands out of 9 , C and D 1 band out of 6. In all patients, the erythema resolved within the treatment period.

No complications secondary to the borrelia infection were registered. After treatment there was no significant change in titre, nor was there a difference in the immunoblot pattern between the first, second and third serum samples. Serum antibodies to B. Immunoblot results offered by borrelia species and by the interpretation criteria, ranging between 8.

After antibiotic treatment of erythema. Lyme disease is an emerging worldwide infectious disease with major foci of endemicity in North America and regions of temperate Eurasia. A survey was designed to assess the ability of the general public to distinguish various appearances of erythema migrans from non-Lyme rashes. Participants were solicited from individuals who visited an educational website about Lyme disease.

Of 3, people who accessed a rash identification survey, A mean of Participants were most familiar with the classic target erythema migrans of Lyme disease but were unlikely to correctly identify the nonclassic erythema migrans. These results identify an opportunity for educational intervention to improve early recognition of Lyme disease and to increase the patient's appropriate use of medical services for early Lyme disease diagnosis.

An ab initio molecular. Matter 14 A curious case of cholestasis: oral terbinafine associated with cholestatic jaundice and subsequent erythema nodosum. Terbinafine is a commonly prescribed antifungal agent used in the treatment of trichophytic onychomycosis and chronic cutaneous mycosis that are resistant to other treatments.

This case report highlights a rarely documented but important adverse hepatic reaction that was caused by the use of oral terbinafine. A woman in her thirties presented with a 3-week history of jaundice, malaise, itching, nausea, decreased appetite, weight loss, dark orange urine and intermittent non-radiating epigastric pain.

She had recently finished a 3-week course of oral terbinafine for a fungal nail infection. Liver biopsy findings were consistent with chronic active hepatitis secondary to a drug reaction. A few days after initial presentation, the patient developed erythema nodosum. Delayed development of erythema nodosum secondary to terbinafine could not be excluded.

Effects of emollients on ultraviolet-radiation-induced erythema of the skin. Several commonly used emollients were studied as to their effectiveness in absorbing and filtering erythema -causing ultraviolet radiation in the to nm range UVB. Therefore, these emollients may interfere with the therapeutic effects of the ultraviolet radiation component of the Goeckerman treatment when it is administered in low doses to patients with psoriasis. Lower eyelid skin is very thin with a low density of adnexal structures.

Attempts to remove rhytides and improve surface appearance with chemical peels and dermabrasion have been disappointing. Laser resurfacing offers a new modality that may improve the outcome. We evaluated a very short duration microsecond s ec pulsed carbon-dioxide laser Tru-PulseTM in terms of healing time duration of erythema and efficacy wrinkle reduction. Female patients aged 35 - 75 received laser resurfacing in a variety of cosmetic zones but only data from lower lids are reported here.

Patients followed a strict regime of post-op wound care. Pre-treatment and follow-up photographs were taken in a studio with constant photographic parameters. Projected 35 mm slides were evaluated side-by-side for clinical improvement and presence of erythema. In our sample the longest duration of post-op lower lid erythema lasted 5 weeks. Regression analysis was used to evaluate the relationships between percent wrinkle reduction and the treatment, demographic, and evaluation variables.

There was a significant trend for wrinkles to improve over the 3 to 9 month evaluation period. Older patients improved slightly more than younger patients. There was no relationship between total energy density and wrinkle reduction. Objective assessment in digital images of skin erythema caused by radiotherapy.

Matsubara, H. Purpose: Skin toxicity caused by radiotherapy has been visually classified into discrete grades. The present study proposes an objective and continuous assessment method of skin erythema in digital images taken under arbitrary lighting conditions, which is the case for most clinical environments.

The purpose of this paper is to show the feasibility of the proposed method. Methods: Clinical data were gathered from six patients who received carbon beam therapy for lung cancer. Skin condition was recorded using an ordinary compact digital camera under unfixed lighting conditions; a laser Doppler flowmeter was used to measure blood flow in the skin. The photos and measurements were taken at 3 h, 30, and 90 days after irradiation. Images were decomposed into hemoglobin and melanin colors using independent component analysis.

Pixel values in hemoglobin color images were compared with skin dose and skin blood flow. The uncertainty of the practical photographic method was also studied in nonclinical experiments. Results: The clinical data showed good linearity between skin dose, skin blood flow, and pixel value in the hemoglobin color images; their correlation coefficients were larger than 0.

Conclusions: Feasibility of the proposed method for assessment of skin erythema using digital images was demonstrated. The numerical relationship obtained helped to predict skin erythema by artificial processing of skin images. Although the proposed method using photographs taken under unfixed lighting conditions increased the uncertainty of skin information in the images, it was shown to be powerful for the assessment of skin conditions because of its flexibility and adaptability.

Immune reconstitution inflammatory syndrome unmasking erythema nodosum leprosum: A rare case report. Full Text Available Immune reconstitution inflammatory syndrome IRIS occurs as an acute symptomatic expression of a latent infection during the recovery of immune system in response to antiretroviral therapy in HIV patients. IRIS triggers both opportunistic and non-opportunistic infections. Full Text Available Background and Design: Although photosensitivity is considered as one of the side effects of retinoids, there is no consensus on this issue.

In this study, we aimed to evaluate the minimal erythema dose MED for narrowband ultraviolet B in patients receiving isotretinoin treatmentMaterial and Method: Phototesting was done by narrowband ultraviolet B irradiation on fifty patients for whom isotretinoin treatment was planned.

MED values were calculated before treatment MED1 and during treatment after reaching half of the target dose kgx mg MED2, and it was evaluated whether there was statistically significant difference between the two MED values. In addition, the patients were assessed according to their skin phototypes in this respect.

When the patients were evaluated according to their skin phototypes, significant difference between the means of MED 1 and MED 2 values was not determined. Conclusion: Although isotretinoin treatment does not cause clinically sunburn erythema , it was associated with decrease in MED values.

Non-ablative nm fractional laser therapy not effective for erythema dyschromicum perstans and postinflammatory hyperpigmentation: a pilot study. Kroon, Marije W. Wietze; Bos, Jan D. Background: Erythema dyschromicum perstans and postinflammatory hyperpigmentation PIH are characterized by papillary dermal pigmentation or pigment incontinence. To date, no standard treatment is available.

Fractional laser therapy FLT was recently reported to improve different pigment. Topical microemulsion containing Punica granatum extract: its control over skin erythema and melanin in healthy Asian subjects. Punica granatum is apotent source of polyphenolic compounds with strong free radicals scavenging activity. The skin lightening effects of Punica granatum are assumed due to ellagic acid which acts by chelating copper at the active site of tyrosinase. Skin erythema and melanin were measured at baseline and after every 15 days to determine any effect produced by these formulations.

Active formulation showed a significant impact on skin erythema and melanin p Punica granatum extract for conditions where elevated skin melanin and erythema have significantly prone skin physiology. Erythema multiforme. This intrusion displays a compositional variation from tonalite to monzogranite, has a medium to coarse inequigranular texture and is locally porphyritic; biotite is the predominant mafic in one of the facies, and hornblende is predominant in the other, with both metamorphosed into the greenschist facies.

The studied rocks characterize an intermediate to acidic sequence that was formed by a subalkaline magmatism; the series is alkali-calcic to metaluminous to slightly peraluminous, and the rocks evolved through fractioned crystallization mechanisms.

Full Text Available Erythema multiforme major EMM is a hypersensitivity reaction usually secondary to medications, viruses or other infections. Its presentation is fairly typical with a symmetrical distribution of vesicles, bullae or targeted lesions on the upper body, arms, legs, palms, feet and oral mucosa. Typical therapies were not initially helpful and intravenous immunoglobulin antibody had to be administered.

Epidemiological and clinical features of erythema infectiosum in children in Novi Sad from to Erythema infectiosum EI is a common childhood illness, caused by human parvovirus B It occurs sporadically or in epidemics and is characterized by mild constitutional symptoms and a blotchy or maculopapular lacy rash on the cheeks slapped-cheek spreading primarily to the extremities and trunk.

The aim of our study was to analyse the epidemiological and clinical characteristics of erythema infectiosum in children. We compared the data about the clinical characteristics during and after the outbreak of EI observed from December to September The data were retrieved from the hospital database. During the study period, EI was detected in 88 children 44 females and 44 males, 0.

An outbreak of erythema infectiosum was observed from December to September , with the peak frequency in April and May and 39 diagnosed cases, and stable number of cases from to a total of 49 diagnosed cases. The average age of infected children was 7. Eleven Pruritus was present in 9. In all the cases the course of the disease was without complications. The results of this study confirm the presence of EI the fifth disease in our area with a mild course in the majority of patients.

Since the diagnosis of EI is usually based on clinical. Time of erythema onset after application of methyl nicotinate ointments as response parameter: influence of penetration kinetics and enhancing agents. The time of erythema onset may be used as a response parameter for quantification of the cutaneous erythema response induced by methyl nicotinate.

The vehicles light mineral oil LMO; test and medium chain triglycerides MCT; standard were compared with regard to the pharmacodynamic response. Moreover, the influence of penetration enhancers on the time of erythema onset was investigated under zero order penetration kinetics. The enhancers dimethyl sulfoxide, diethylene glycol monoethyl ether and three different glycerides in different concentrations were added to MCT as a standard vehicle. All preparations were applied to the forearms of volunteers under infinite dose conditions at different thermodynamic drug activity levels 0.

Different penetration kinetics do not influence data of erythema onset, as these data are comparable to those obtained under finite dose conditions first order penetration kinetics. With regard to the penetration enhancers, a significantly enhanced penetration of methyl nicotinate could be observed only for diethylene glycol monoethyl ether and dimethyl sulfoxide. However, no significant difference between light mineral oil and MCT could be found with regard to penetration enhancement.

The time of erythema onset is an easy and efficient parameter for quantification of the pharmacodynamic response caused by nicotinates. Erythromycin as a safe and effective treatment option for erythema annulare centrifugum. It is usually self-limited, but chronic disease may be difficult to treat. We observed incidentally the therapeutic effect of erythromycin for EAC among patients taking erythromycin for other diseases. Aim: To evaluate the treatment response of erythromycin for EAC. Materials and Methods: During the study period, from July to February , all patients with EAC were assigned to erythromycin stearate tablet mg per day for two weeks.

EAC was diagnosed by a constellation of clinical and pathological findings. The efficacy before and after the treatment was assessed clinically by one dermatologist and photographically by two blinded dermatologists. Secondary outcomes included adverse drug effects and recurrence. Results: Eight patients were enrolled in this study. Most patients had chronic relapsing disease with poor response to previous treatment. All the patients showed rapid response with profound reduction in the size of lesion and erythema two weeks after initiation of erythromycin treatment.

The response was so obvious and complete that a coincidental response was less likely. Three patients had recurrence of disease and they tended to have more extensive lesions. Readministration of erythromycin was effective. All patients tolerated the treatment well. Conclusion: Our study documented erythromycin as a safe and cost-effective treatment for EAC. Full Text Available Erythema annulare centrifigum is a dermatose which is frequently seen in adults.

It is characterized by erythematous lesions which spread asymmetrically to periphery and have a collarette desquamation. Although infection, tumor, food allergy, drug reaction can play a role in the aetiology, most of the cases are idiopathic. A forty-nine years old, female patient presented to our clinic with erythematous lesions on both of her lower extremities. Six weeks prior to her referral, she treated with quinine for Sjogren syndrome.

She had a diagnosis of granuloma annulare in her personal history. There was no significance in her family history. In dermatologic examination; annular erythematous plaques and collarette desquamation were detected on lower extremities. Histopathologic examination of the lesional biopsy specimen revealed focal spongiosis in the epidermis, dermal oedema, vascular proliferation and perivascular infiltration of lymphocytes, eosinophils and histiocytes. In the laboratory examination; blood count, liver and kidney function tests, sedimentation, C-reactive protein was normal.

Rheumatoid factor was Development and clinical validation of a novel photography-based skin erythema evaluation system: a comparison with the calculated consensus of dermatologists. Erythema is the most common presenting sign in patients with skin diseases, and various methods to treat erythema symptoms have become common. To evaluate changes in erythema , a reliable device that can support objective diagnosis is required. We developed a novel photography-based system for erythema diagnosis that provides a high-resolution three-view photograph taken in a consistent photography environment with a curved surface light source and can be integrated with optimized image processing algorithms.

A new diagnostic algorithm was applied to photographs from 32 patients to determine areas of erythema automatically. To assess the performance in comparison to dermatologists' evaluations, five dermatologists independently evaluate the areas of erythema , and we defined an area called the clinical consensus area of erythema CCAE , which is based on the majority opinion of dermatologists during evaluation.

The CCAE values obtained were compared with the erythema areas determined by the system's diagnostic algorithm. Forty-one photographs with areas of erythema were evaluated by the proposed system and by dermatologists. The results obtained with the proposed system had a mean accuracy of The results also showed that the proposed system could detect erythema areas without any pigmentation. In contrast to assessments by individual dermatologists, use of the CCAE reduced the amount of error that occurred owing to bias or subjectivity.

A new erythema evaluation system was developed and validated through CCAE, suggesting that the system can support dermatologists' objective diagnoses of erythema. But the referential pattern that emerges from the dramatic plot clearly points beyond eighteenth-century time and space in partly overt and mostly covert ways: to the early twentieth-century post-Trianon fate of the Hungarians in Transylvania, and beyond, to the destructive post totalitarian communist regime in Hungary, as well as to the backlash of the anticommunist and anti-Soviet revolution and war of independence.

The narrative techniques of expanding early eighteenth-century time and space will be examined through the ways in which thematic threads of collective identity are woven in the novel in general, and the customs, habits, and the religious affiliation of the community are handled in particular.

Ultraviolet erythema as an indicator of nonspecific reactivity during hemorrhagic vasculitis in children. From to studies were carried out on children suffering from hemorrhagic vasculitis. For patients in the severe stage of hemorrhagic vasculitis it is characteristic that there are functional shifts in the central nervous system, which are manifested by a changed sensitivity of the skin to ultraviolet irradiation.

The appearance of slowed, inert or paradoxal reactions indicates the predominance of processes in the brain that slow down and decrease the reactivity of the organism. In rheumatoid and abdominal-rheumatoid syndromes of the disease, disturbances in indices to skin light-sensitivity are the most manifest. During the recovery period, the indices of ultraviolet erythema , on approaching normal values, still remain low. This behavior requires extensive outpatient observation and treatment of sick children to avoid recidivism.

Histopathological study of ocular erythema nodosum leprosum and post-therapeutic scleral perforation: A case report. Full Text Available Leprosy is a chronic granulomatous disease caused by Mycobacterium leprae , clinically present either as tuberculoid, borderline or lepromatous type. Erythema nodosum leprosum ENL is an acute humoral response in the chronic course of lepromatous leprosy.

Although very severe ENL reactions are known in systemic leprosy, such severity is rare in ocular tissues. A leprosy uveitis patient suffered from a severe form of post-therapeutic ENL reaction which resulted in perforation of the globe at the site of preexisting subconjunctival leproma.

Painful blind eye was enucleated. Histopathological study revealed infiltration of numerous polymorphs and macrophages packed with acid-fast bacilli in the conjunctiva, cornea, ciliary body, ora serrata and sclera. A profuse influx of neutrophils on a background of macrophages packed with M. This case is reported to alert the ophthalmologists to a rare ocular complication of ENL.

Cytological diagnosis of erythema nodosum leprosum in clinically unsuspected cases: A report of two cases. Full Text Available Leprosy is a chronic infectious disease caused by Mycobacterium leprae. The manifestations of this disease varies across the spectrum of tuberculoid TT to lepromatous LL leprosy. The course of this indolent disease is interrupted by acute exacerbations in the form of leprare actions.

Erythema nodosum leprosum ENL, a type 2 lepra reaction, occurs in lepromatous or borderline lepromatous cases, usually in response to multidrug therapy. Early detection and timely management of these patients is important to reduce the associated morbidity.

We report two clinically unusual cases of ENL on fine-needle aspiration cytology. In one case, antileprosy treatment was completed 10 years back, whereas in the other case, ENL was the presenting feature of the disease. Cytological examination of swelling in both the cases showed neutrophils, lymphoid cells, clusters of foamy macrophages, histiocytes, and giant cells.

Fite stain was positive, which confirmed the cytological diagnosis of ENL.

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Creating Art Installation in Virtual Reality. The Stilleben Project. Converging Data Storytelling and Visualisation. Workshop on Robot Competitions. Imperceptible Art. Designing Entertainment for the Aging Population.

Paula Alexandra Silva, Masood Masoodian. The 15 full papers, 13 short papers, and 23 poster, demostration, and workshop papers presented were carefully reviewed and selected from 65 submissions. They cover a large range of topics in the following thematic areas: digital games and interactive entertainment; design, human-computer interaction, and analysis of entertainment systems; interactive art, performance and cultural computing; entertainment devices, platforms and systems; theoratical foundations and ethical issues; entertainment for purpose and persuasion; computational methodologies for entertainment; and media studies, communication, business, and information systems.

Editors and affiliations. Fluminense Federal University Niteroi Brazil 2. University of Coimbra Coimbra Portugal 3. Curtin University Perth Australia 4. Tampere University of Technology Pori Finland. Buy options.

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